About half of early miscarriages happen because the pregnancy had the wrong number or arrangement of chromosomes, usually by chance. Testing can sometimes show this, and many people find that knowing helps them understand what happened. It is optional, it cannot always give an answer, and it does not change the treatment options above.
On the NHS, chromosome testing of pregnancy tissue is usually offered from the third miscarriage, after any miscarriage from 14 weeks, or sooner in some situations, such as when a scan has shown features that suggest a chromosome condition. After a first or second early miscarriage it is not routinely offered, although it is always worth asking your unit.
A blood-based test reads placental DNA in your blood, so it is best taken while the tissue is still in the womb, after a scan has checked that it is there. In a 2026 Danish study of 1,463 women, levels fell significantly more than 12 hours after the tissue passed, and more tests failed to give a result.
These blood tests are not part of standard NHS care, and the result is closer to screening than a final answer. Across eight studies they picked up about 78 in 100 of the chromosome changes that tissue testing found; some 'abnormal' results did not match the tissue, and some samples gave no result. Triploidy (a whole extra set of chromosomes) is usually missed.
Tissue testing examines the pregnancy tissue itself, usually with a rapid test for the commonest chromosome changes plus a chromosomal microarray, and it needs fresh tissue. Our guide to blood or tissue testing compares the two, and our genetic counsellors can talk through your options in a 30-minute video appointment.