Also called anembryonic pregnancy
Empty gestational sac
A blighted ovum, or anembryonic pregnancy, is when a pregnancy sac grows in the womb with no embryo developing inside. It often follows a chance chromosome change and is not caused by anything you did. Here we explain how it is confirmed, why it happens and when testing may help.
One scan showing an empty sac is not always the final word, and NICE sets out when a repeat scan or second opinion is needed first. If you are thinking about genetic testing, some options are only possible while the pregnancy is still in the womb, so it is worth asking early; our CLARITY blood test is one of them.
Available atLPC City (E1)
The basics
After a fertilised egg implants in the womb, two things normally develop together: the pregnancy sac with its early placenta, and the embryo inside it. With a blighted ovum, the sac and placental tissue form and keep growing, but the cells that should become the embryo stop developing very early and are reabsorbed by the body. A scan then shows a sac with no embryo in it, sometimes reported as 'no fetal pole'.
Many clinicians now prefer the term anembryonic pregnancy, meaning 'without an embryo', and many people find 'blighted ovum' upsetting. It is still widely used in hospitals, though, so you may see either name in your notes, or hear it called an empty sac or empty gestational sac. All of them describe the same type of early miscarriage, and it is a common one.
Because the placental tissue keeps working for a while, pregnancy hormone levels can stay high. Home tests stay positive, and a missed period, sore breasts and sickness can all carry on as normal. That is why many people have no idea anything is wrong, and why the diagnosis at a scan can come as such a shock.
Researchers think development stops by around the fifth week of pregnancy, yet the sac can keep growing for weeks and look like a developing pregnancy. Most anembryonic pregnancies are diagnosed between 8 and 13 weeks, often at a first or routine early scan, so there can be a long gap between the pregnancy stopping and anyone knowing.
Telling them apart
Three early scan findings are easily confused. Only the clinician who has seen your images can say which one applies to you.
The sac has grown, but no embryo is visible inside it. The embryo never formed or stopped extremely early, leaving only the supporting structures of the pregnancy. It is counted as a type of missed miscarriage, and because the sac keeps growing the loss can go unrecognised for weeks.
An embryo developed far enough to be measured, then stopped, so the scan shows an embryo with no heartbeat. Read more about missed miscarriage.
The sac is still small, under 25 mm on an internal scan, and nothing is visible inside it yet. This may be a healthy pregnancy that is younger than the dates suggest, which is why NICE advises a repeat scan at least 7 days later before any diagnosis.
Once an empty sac has been confirmed under the NICE checks, it stays in your womb until it passes or is treated, and the placental tissue can still release DNA into your blood. Our CLARITY blood test analyses that DNA from a single sample, so it can be done even though no embryo formed; if you are considering it, have the blood test as soon as you can after diagnosis, before any tablets or procedure, and tell the team treating you. It costs £530, results usually come within 7 working days of the laboratory receiving the sample, and you can book CLARITY online.
Diagnosis
In the UK, NICE guidance sets out how an anembryonic pregnancy should be diagnosed. An internal (transvaginal) scan is offered first because it gives the clearest view. If no embryo can be seen, the sonographer measures the mean gestational sac diameter, which is the average size of the sac.
The rules are deliberately cautious. A single scan cannot be guaranteed to be 100% accurate, and mistakes are most likely very early in pregnancy, so the guidance builds in time and a second check.
| What the scan shows | Type of scan | What NICE recommends before a diagnosis |
|---|---|---|
| Sac under 25 mm, no embryo visible | Internal (transvaginal) | A second scan at least 7 days later; further scans may be needed |
| Sac 25 mm or more, no embryo visible | Internal (transvaginal) | A second opinion on the scan, a repeat scan at least 7 days later, or both |
| No embryo visible, any sac size | Abdominal scan only | Record the sac measurement, then repeat the scan at least 14 days later |
NICE also says the date of your last period may not show accurately how far along you are, because cycles vary, so it should not be used on its own to decide whether a heartbeat ought to be visible. Waiting for a repeat scan does not harm the pregnancy.
Blood hCG tests are not part of NICE's criteria for diagnosing a miscarriage in the womb. NICE uses them mainly when the location of a pregnancy is not yet known.
Waiting
Being asked to come back in a week or two is hard, but the wait has a purpose. You may have ovulated later than your dates suggest, particularly if your cycles are irregular, so the pregnancy may simply be younger than expected. Very early pregnancies may not show an embryo yet even when all is well, and a repeat scan gives one time to appear.
If the second scan still shows no embryo where one would clearly be expected, the diagnosis can usually be made with confidence. While you wait, contact your early pregnancy unit if you have heavy bleeding or pain. NICE says you should be given a 24-hour number to speak to someone experienced in early pregnancy problems.
Telling a very early, healthy pregnancy apart from an anembryonic one can be subtle and relies on experience in early pregnancy scanning and good equipment. An accurate, timely answer lets you make informed decisions and begin to come to terms with what has happened, while a wrong or delayed one adds to the distress. If you would like an independent specialist view, a second-opinion scan is available alongside your NHS care.
These figures describe groups of pregnancies, mostly analysed with traditional chromosome tests, and cannot tell you the cause of any one loss. The studies are listed at the foot of this page.
Causes
In most cases the cause is thought to lie in the pregnancy itself. An embryo needs the right number of chromosomes, the packages that carry our genetic instructions, to develop. When a chromosome is extra or missing, or there is a whole extra set, development can stop before an embryo is ever visible. In two studies of anembryonic pregnancies, close to 6 in 10 of those tested had a chromosome change, a similar share to miscarriages where an embryo was seen.
These changes usually happen by chance, as the egg or sperm forms or in the first cell divisions after fertilisation. They are not usually inherited, and the parents' own chromosomes are normally healthy. The problem was present from the very start, which meant the pregnancy could not develop. It is not caused by anything you did or did not do, and it could not have been prevented.
An extra copy of one chromosome (a trisomy) is the most common finding. In the large Russian series, trisomies were found in about 28 in 100 anembryonic pregnancies. A doubled set of chromosomes (tetraploidy) was more common than in losses with an embryo, including when rechecked on uncultured tissue, while triploidy (a single extra set) and changes in the number of sex chromosomes, such as a missing X, were less common.
Age plays a part. As women get older, the number and quality of their eggs decline, and chromosome errors become more common. The NHS lists being 35 or over among the things that raise the chance of miscarriage. Even so, a blighted ovum can happen at any age, and most cases are random events.
When testing shows normal chromosomes, the cause may still be genetic at a level standard tests cannot see, such as very small chromosome changes or a change in a single gene. After repeated losses, doctors also look for causes in the mother; our recurrent miscarriage page explains those investigations.
Genetic testing
Testing is a personal choice, and it cannot always find a cause. With an anembryonic pregnancy there is no embryo to test, but the placental tissue grows from the same fertilised egg, so its chromosomes can be checked instead. Which route is open to you depends on where you are now; this guide to what you can test now sets out the options.
The placenta releases tiny fragments of its DNA into your bloodstream. A blood-based test (a cell-free DNA test, which works on the same principle as NIPT) counts these fragments to look for extra or missing chromosomes. Because the DNA comes mainly from placental cells, the test can still be done when no embryo has formed: a small Bristol study found normal levels of this DNA in pregnancies with an empty sac.
Timing matters. Placental DNA in the blood is highest while the tissue is still in the womb and falls once it has passed or been removed. In a large Danish study, about 1 in 11 samples taken with the tissue in place gave no result, rising to more than 1 in 4 when taken 12 to 24 hours after it had passed. A scan shortly before the sample confirms the sac is still there.
This is a screening test, not a final answer. Across studies it picked up about 78 in 100 of the chromosome changes found in tissue, and about 1 in 10 pregnancies with normal tissue results were wrongly flagged. Most methods cannot detect extra whole sets of chromosomes, which occur in some empty-sac pregnancies.
Blood-based testing after a miscarriage is not part of routine NHS care. We offer it as CLARITY: £530 covers the blood draw at our City clinic, the laboratory analysis and an explanation of the result from our clinician, and you can book it online. Like most of these methods, CLARITY does not detect triploidy or other extra whole sets of chromosomes. If you are unsure whether it suits your situation, our genetic counsellors can talk it through with you.
Once the pregnancy has passed or been removed, the tissue itself can be tested. An empty sac may contain little or no embryonic tissue, but the placental tissue (chorionic villi) is what laboratories normally analyse, and studies of anembryonic pregnancies show it can give useful chromosome results.
Many laboratories now use a chromosomal microarray, which reads DNA directly and does not need cells to grow. Traditional karyotyping relies on growing living cells and fails in about 1 in 5 samples. Sometimes the mother's cells are tested by mistake, which can make the result look like a normal female pregnancy; a SNP-based array or a sample of the mother's blood can check for this.
The tissue should reach the genetics laboratory fresh and quickly. Tissue placed in formalin, the preservative used for routine pathology, is usually unsuitable, so tell your team before treatment that you would like genetic testing. Our page on pregnancy tissue testing explains the process.
On the NHS, chromosome testing of pregnancy tissue is usually offered from the third miscarriage onwards and after any miscarriage from 14 weeks, or sooner if there are features suggesting a chromosome condition. After a first anembryonic pregnancy it is not routinely offered, although you can ask your early pregnancy unit. Private testing is possible after a single loss, and our genetic testing and counselling team can explain the options first.
If no tissue was tested, the cause of this loss cannot be confirmed afterwards. Testing the parents' chromosomes is not routine after one miscarriage. UK guidance reserves it for couples whose pregnancy tissue showed an unbalanced rearrangement, or who have had recurrent miscarriages where tissue could not be tested; see parental chromosome testing.
Treatment
Once the diagnosis is certain, there are three ways to complete the miscarriage. Unless you need urgent treatment, you should usually be able to choose, and your team will explain which options suit your circumstances. Each one affects whether and how genetic testing can be done, so it helps to think about testing first.
Expectant
NICE recommends waiting for 7 to 14 days as the first option for most people. It avoids medicines and procedures and can feel more natural, but it may take several weeks and needs monitoring, and some people find the uncertainty hard. While you wait, the sac is still in the womb, so a blood-based test such as CLARITY may still be possible.
Medical
For a missed miscarriage, which includes an empty sac, NICE recommends 200 mg of mifepristone by mouth, then 800 micrograms of misoprostol 48 hours later. You can expect cramping and bleeding, as with a natural miscarriage; contact your unit if bleeding has not started within 48 hours of the misoprostol. It is often quicker than waiting and gives you more control over timing. A home pregnancy test 3 weeks later checks it is complete.
Surgical
The tissue is removed through the cervix with gentle suction, either awake with local anaesthetic in a clinic (manual vacuum aspiration) or asleep under general anaesthetic in theatre. It usually takes 10 to 15 minutes, you can normally go home the same day, and it is sometimes still called a D&C. It suits people who want a quick resolution, have a higher risk of heavy bleeding or infection, or whose other treatment has not worked, and tissue can be collected for testing.
From a study at St George's Hospital early pregnancy unit of 92 women who chose to wait after an anembryonic pregnancy was diagnosed (Luise et al., 2002). Times are counted from diagnosis, not from when the pregnancy stopped, and at the time surgery was the only alternative offered.
Coping
For many couples the first scan is one of the most anticipated moments of pregnancy, so learning that the sac is empty can be devastating. You may already have pictured the future or shared your news. Because symptoms often carry on as normal, the diagnosis can feel unreal, and it is natural to wonder whether the scan could be wrong.
Some people worry that they have less right to grieve because the scan never showed an embryo. There is no right way to feel: you were pregnant, and the loss is real. Many also wonder whether they caused it, and feel guilty. A blighted ovum is a chance event, not the result of anything you did.
Support is available from your GP or early pregnancy unit, and from Miscarriage UK (0303 003 6464) and Tommy's (0800 0147 800). In England you can also request a baby loss certificate to recognise your loss. Our miscarriage care page describes the support we offer in London.
Looking ahead
Another anembryonic pregnancy can happen, but it is unlikely. A single anembryonic pregnancy is a chance event and does not, on its own, point to a fertility problem. Most people who have one go on to have a healthy pregnancy, and the NHS notes that most women who have had a miscarriage go on to have a successful pregnancy in the future.
If testing did find a chromosome change, the outlook for the next pregnancy is generally better than when a lost pregnancy had normal chromosomes, although age still matters, and this may not apply if a parent is found to carry a chromosome rearrangement.
The NHS advises that you can try for another pregnancy when you feel ready, once your symptoms have gone. Your first period can take up to 8 weeks to return. Some couples choose to wait for it before trying, but that is a personal choice. Taking folic acid before you conceive is recommended for every pregnancy.
If you have had three or more miscarriages, talk to your GP, who will usually refer you for tests. In a new pregnancy an early scan can bring reassurance; our viability scan checks the pregnancy is in the womb and looks for a heartbeat from 6 weeks.
Alongside your NHS care
Your NHS early pregnancy unit remains the right place for repeat scans, treatment and urgent care, all free of charge. If you would like extra support alongside it, our team can help at our City of London and West London clinics or online.
Before treatment, City clinic
There is no embryo to test, but placental tissue releases DNA into your blood, so one sample at our City clinic can still look for extra or missing chromosomes. It must be taken before tablets, surgery or the sac passing, and our clinician explains the result.
Uncertain scan
From around 10 weeks, an independent scan with Dr Fred Ushakov if you would like another specialist view of an empty sac before decisions are made.
Testing questions
A 30-minute video appointment with a registered genetic counsellor about blood-based and tissue testing, timing, and what a result can and cannot tell you.
Complex results
With Dr Harry Leitch, Consultant in Clinical Genetics, if a result needs expert interpretation or raises questions for a future pregnancy.
Next pregnancy
An early scan at 6 to 9 weeks in a new pregnancy to confirm it is in the womb and check for a heartbeat.
Yes. All three describe a pregnancy sac that has developed without an embryo inside it. Many clinicians now prefer 'anembryonic pregnancy', but 'blighted ovum' still appears in hospital notes and scan reports.
Sometimes, very briefly. In some cases the cells that would have formed the embryo start to develop, then stop at a very early stage and are reabsorbed before they can be seen on a scan; in others an embryo does not form at all. Either way, the sac and placental tissue carry on growing, which is why the sac looks empty.
Not yet. Under NICE guidance, a sac under 25 mm on an internal scan with no visible embryo needs a repeat scan at least 7 days later before a miscarriage can be diagnosed, because the pregnancy may simply be younger than your dates suggest. Waiting does not harm the pregnancy.
Not on their own. In the UK, a miscarriage in the womb is diagnosed from the scan measurements set out by NICE. Because the placental tissue can keep making pregnancy hormone for a while after development stops, an hCG result on its own cannot confirm or rule out an anembryonic pregnancy.
The placental tissue, which grows from the same fertilised egg. Laboratories test this tissue after a miscarriage, and blood-based tests read DNA released by the placenta, so neither needs an embryo to have formed. See testing before a miscarriage completes for the time-sensitive option.
You can, once the diagnosis has been confirmed, as long as the sac is still in your womb and it is a single pregnancy rather than twins or more. Because CLARITY reads DNA from the placental tissue, it does not need an embryo to have formed. The blood must be taken before any tablets or procedure and before the sac passes naturally; it is not suitable once the womb has emptied.
It does not detect extra whole sets of chromosomes, such as triploidy or tetraploidy, which are found in some empty-sac pregnancies, and a result with no change found does not rule out a genetic cause. It costs £530, results usually come within 7 working days of the laboratory receiving the sample, and our clinician explains the result.
No. Surgery is one of three options, alongside waiting and taking tablets. The procedure now uses gentle suction and can be done under local or general anaesthetic. The right choice depends on your preferences, your health and whether there is a higher risk of heavy bleeding or infection.
Usually not. Most people go on to have a healthy pregnancy after an anembryonic pregnancy. If you have had three or more miscarriages, ask your GP about investigations; our recurrent miscarriage page explains what is usually checked.
This guide describes an anembryonic pregnancy in general terms. It cannot replace advice from the clinicians who know your history and have seen your scans. If you have heavy bleeding, severe pain or a high temperature, or you feel faint, contact your early pregnancy unit or call NHS 111, and call 999 in an emergency.
Contact
The figures and clinical statements on this page are drawn from the sources below. Guidance evolves — always discuss your individual circumstances with a clinician.
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