Testing the pregnancy tissue
Pregnancy tissue can be tested after surgical or medical management, or sometimes after a miscarriage at home if the tissue is collected. Many laboratories now use a chromosomal microarray, which analyses the DNA directly without needing cells to grow; older karyotyping needs living cells and fails in about 1 in 5 samples.
For a usable result, the tissue needs to reach the laboratory fresh, in a sterile container and without preservative. Tissue that has been put into formalin, the preservative normally used when tissue is examined under a microscope, is generally unsuitable. If you would like testing, tell your team before treatment so that a fresh sample can be set aside.
In the UK, RCOG guidance recommends offering chromosome testing of the tissue from a third or later miscarriage, or any miscarriage in the second trimester; NHS laboratories also accept tissue when there are particular features, such as a structural abnormality seen on a scan. Otherwise it is not usually offered after a first or second early loss, though some people arrange it privately. Read more about pregnancy tissue testing.